Antibiotics

Antibiotic resistance is now one of the greatest threats to global health, food security and development. In our group we investigate the mechanism of resistance to ribosome-targeting antibiotics mediated by ABCF proteins conferring resistance to several groups of clinically important antibacterial agents, e.g. macrolides and lincosamides. With the focus on the primary role of antibiotics and the corresponding resistance determinants in the natural environment, we explore the evolutionary mechanisms leading from cell signaling and regulatory molecules to antimicrobial resistance. A better understanding of the principles of antibiotic-resistance (ARE) ABCF function and resistance evolution could provide strategies for developing new interesting compounds and approaches to overcome this type of resistance.