Laboratory of Antibiotic Resistance and Microbial Metabolism
Kamenik & Balikova Novotna Lab
BIOLOGY AND CHEMISTRY OF MICROORGANISMS
Our main area of focus is on the metabolites produced by various microorganisms, investigating their biosynthesis and functions. With two teams located in the Krč campus in Prague and in Biocev in Vestec, we are deepening our understanding of the microbial world through rigorous research and collaboration. Join us in exploring the exciting world of microorganisms!
Microorganisms produce a broad spectrum of remarkable metabolites that we utilize as antibiotics, immunosuppressants, or anticancer drugs. We work on uncovering their biosynthesis, i.e., how bacteria make these complex molecules. Using state-of-the-art techniques of genetic engineering, enzymology, organic synthesis, and analytical chemistry, we aim to come up with novel more efficient antibiotics or other drug-leads.
We have set up a platform for metabolomics, which aims to characterize a complex picture of small organic molecules in a sample. Together with information from other OMICs approaches, it enhances our understanding of living systems. Our strategy is based on recently developed computational tools and mass spectrometry technique, employing the recently acquired state-of-the-art TimsTOF instrument with ion mobility.