Development of new strategies for the protection of human health
MICROBIOLOGY, BIOCHEMISTRY, METABOLOMICS
Our main area of focus is on the metabolites produced by various microorganisms, investigating their biosynthesis and functions. With two teams located in the Krč campus in Prague and in Biocev in Vestec, we are committed to advancing our understanding of the microbial world through rigorous research and collaboration. Join us in exploring the exciting world of microorganisms!
Microorganisms belong the greatest source of specialized bioactive metabolites. We work on uncovering their biosynthesis, i.e., how bacteria make these complex molecules. Using state-of-the-art techniques of genetic engineering, enzymology, and chemical analysis, we aim to come up with novel more efficient antibiotics or other drug-leads.
We have set up a platform for metabolomics, which aims to characterize a complex picture of small organic molecules in an organism. Together with information from other OMICs approaches, it enhances our understanding of living systems. Our strategy is based on mass spectrometry and recently developed computational tools.
Resistance to Antibiotics
Resistance to current antibiotics is becoming global public health threat. We collaborate with Czech hospitals to get insight into one of the most problematic resistance mechanisms: methylation of ribosome. This research also revealed how microorganisms communicate with each other using natural antibiotics.