Development of new strategies for the protection of human health

Janata laboratory

MICROBIOLOGY, BIOCHEMISTRY, METABOLOMICS

Gathering of Otto Wichterle Laureates

May 25, 2023June 1, 2023

May 15th -18th 2023, 22nd Interdisciplinary Meeting of Young Life Scientists, Milovy, Czech Republic

May 16, 2023June 12, 2023

HDDC2023

May 15, 2023June 5, 2023

Bioprosp_23

March 24, 2023June 5, 2023

60th Anniversary of the Institute of Microbiology

September 8, 2022May 24, 2023

Lab BBQ Party

August 9, 2022May 24, 2023

Research Focus

Our main area of focus is on the metabolites produced by various microorganisms, investigating their biosynthesis and functions. With two teams located in the Krč campus in Prague and in Biocev in Vestec, we are committed to advancing our understanding of the microbial world through rigorous research and collaboration. Join us in exploring the exciting world of microorganisms!

Biosynthesis

Microorganisms belong the greatest source of specialized bioactive metabolites. We work on uncovering their biosynthesis, i.e., how bacteria make these complex molecules. Using state-of-the-art techniques of genetic engineering, enzymology, and chemical analysis, we aim to come up with novel more efficient antibiotics or other drug-leads.

Metabolomics

We have set up a platform for metabolomics, which aims to characterize a complex picture of small organic molecules in an organism. Together with information from other OMICs approaches, it enhances our understanding of living systems. Our strategy is based on mass spectrometry and recently developed computational tools.

Resistance to Antibiotics

Resistance to current antibiotics is becoming global public health threat. We collaborate with Czech hospitals to get insight into one of the most problematic resistance mechanisms: methylation of ribosome. This research also revealed how microorganisms communicate with each other using natural antibiotics.