Thesis
Running thesis
| Name | Started | Type | Title |
| Michal Adámek | 2025 | dissertation | Mass spectrometry with trapped ion mobility for isomer separation in microbial metabolomics |
| Marie Kuchařová | 2024 | diploma thesis | |
| Tereza Chlumská | 2024 | diploma thesis | Characterization of a novel type 23S rRNA methyltransferase as a mechanism of macrolide resistance in Clostridioides difficile |
| Kateryna Trufan | 2024 | diploma thesis | Mechanism of regulation of lincomycin biosynthesis by LmrC protein: role of ribosome-mediated antitermination |
| Lucie Šírová | 2024 | diploma thesis | Mechanisms of resistance to pleuromutilins in Streptomyces coelicolor |
| Mufarrah Mehboob | 2023 | dissertation | Exploring the Antibiotic-Responsive Regulatory function of ABCF Proteins in Antibiotic-Producing Bacteria |
| Natálie Zárybnická | 2023 | diploma thesis | Homologs of eukaryotic histone methyltranferases in the biosynthesis of bacterial metabolites: structure and function elucidation |
| Ondřej Hřebíček | 2022 | dissertation | Development of bioinformatics software for targeted analysis of gene clusters, and its application to study the biosynthesis of bacterial metabolites with an unusual 4-alkyl-L-proline motif |
| Baraa Jadala | 2022 | dissertation | The benefit of 4-alkyl-L-proline motif for biological activity of microbial metabolites with distinct modes of action |
| Anna (Jelínková) Michl | 2021 | dissertation | LC/MS identification of new biomarkers in mouse gnotobiotic models of human civilization diseases |
| Michaela Novotná | 2021 | dissertation | Regulation of gene expression of antibiotic resistance ABCF proteins and their role in the regulation of translation |
| Michaela Plechatá | 2021 | dissertation | Structural and functional diversity of bioactive specialized metabolites produced by Actinobacteria |
| Lada Hanzlíková | 2019 | dissertation | Genome mining towards novel metabolites with 4-alkyl-L-proline moieties |
| Magdaléna Lenartová | 2015 | dissertation | Biosynthesis of pyrrolobenzodiazepines and related natural compounds |
Defended thesis
| Name | Finished | Type | Title |
| Emma Polomská | 2025 | diploma thesis | Unraveling new bioactive metabolites with alkylproline motif through gene cluster expression and chemical structure elucidation |
| Jakub Musil | 2024 | diploma thesis | Mechanism of gene expression regulation controlled by the ribosome-binding ABCF ATPase LmrC |
| Lucie Korbová | 2024 | diploma thesis | The role of LmbF and CcbF proteins in the biosynthesis of the antibiotics lincomycin and celesticetin and their potential application in the biosynthesis of the hybrid antibiotic celin |
| Eliška Mašková | 2023 | diploma thesis | The role of ABCF ATPases in the regulation of translation in Staphylococcus aureus |
| Veronika Zachovalová | 2023 | diploma thesis | Detailed characterization of SAM-dependent methyltransferase from lincomycin biosynthesis at the amino acid level |
| Kateřina Nováková | 2023 | diploma thesis | Evaluation of antimicrobial activity of soil actinomycete metabolites against multi-resistant bacterial pathogens |
| Jan Kýr | 2023 | diploma thesis | Cellular factors influencing the antibiotic resistance by ABCF proteins |
| Gioele Pecin | 2022 | diploma thesis | Alternative APD pathway producing strictly 3-C side chain metabolites with an 4-alkyl-L-proline |
| Ondřej Hřebíček | 2022 | diploma thesis | Enzymatic modifications of 4-alkyl-L-proline derivatives incorporated in specialized metabolites of Actinobacteria |
| Lukáš Kekrt | 2022 | diploma thesis | The role of F420-dependent oxidoreductases in actinobacteria |
| Martin Kurečka | 2022 | bachelor thesis | Interactions between Schistosoma spp. and their hosts at the metabolome level |
| Jakub Lenart | 2022 | dissertation | Critical sites determining the resistance phenotype of ABC proteins from the ARE subfamily and the molecular mechanism of their function |
| Šimon Vobruba | 2021 | dissertation | Study of the key points of lincomycin and celesticetin biosynthesis |
| Monika Bartalová | 2021 | diploma thesis | Evaluation of antimicrobial activity of actinomycete metabolites against clinically important bacterial pathogens |
| Anna Jelínková | 2021 | diploma thesis | Development of LC-MS method for untargeted metabolomics of polar compounds |
| Michaela Novotná | 2021 | diploma thesis | Mechanism of inducible gene expression of resistance protein Vga(A)LC from Staphylococcus haemolyticus |
| Barbora Těšínská | 2020 | diploma thesis | Complex characterization of subgingival plaque – use of modern sequencing methods in diagnostics and monitoring of treatment of periodontal diseases |
| Bianka Micke | 2020 | bachelor thesis | The function of ABCF proteins in bacteria |
| Lucie Steiningerová | 2020 | dissertation | The role of F₄₂₀H₂-dependent reductases in the biosynthesis of microbial bioactive metabolites incorporating a 4-alkyl-˪-proline derivate |
| Petra Jirásková | 2020 | dissertation | Biosynthesis of propylproline building unit of lincomycin |
| Bára Seidlová | 2020 | diploma thesis | Ergothioneine and mycothiol in the biosynthesis of lincosamides |
| Jan Kýr | 2020 | bachelor thesis | The function of ClpX chaperone in bacteria |
| Lada Brázdová | 2019 | diploma thesis | Products characterization of bacterial strains encoding the biosynthesis of alkylprolin derivatives |
| Lukáš Cudlman | 2019 | diploma thesis | Analysis and isolation of intermediates involved in the biosynthetic pathway of alkylproline derivatives |
| Michaela Novotná | 2018 | bachelor thesis | Control of the gene expression by cis-acting non-coding RNAs and their importance in regulating genes conferring resistance to antibiotics |
| Nikola Pinďáková | 2018 | diploma thesis | Characterization of the ABC-F protein Sco0636 in Streptomyces coelicolor |
| Jana Prášilová | 2018 | diploma thesis | Development and genetic basis of glycopeptide resistance in coagulase-negative staphylococci |
| Bich Nguyen Thi Ngoc | 2018 | diploma thesis | Subcellular localization of resistant proteins Vga(A)LC and Msr(A) using fluorescence microscopy |
| Barbora Těšínská | 2018 | diploma thesis | Complex characterization of subgingival plaque – use of modern sequencing methods in diagnostics and monitoring of treatment of periodontal diseases |
| Lucie Palánová | 2017 | diploma thesis | Identification of secondary metabolites in bacteria that contain the biosynthetic gene clusters of pyrrolobenzodiazepines |
| Vít Rynd | 2017 | diploma thesis | The development of LC-MS method for determining precursors of dicarboxylic lincomycin |
| Magdaléna Pavlíková | 2015 | diploma thesis | The identification of biosynthetic clusters in the soil isolates of actinomycetes. |
| Lucie Steiningerová | 2015 | diploma thesis | Common features of the biosynthetic pathways of lincomycin,some pyrrolo-1,4-benzodiazepines and hormaomycin |
| Šimon Vobruba | 2015 | diploma thesis | The substrate specificity of adenylation domains of synthetases in secondary methabolism |
| Leona Zieglerová | 2015 | diploma thesis | The effect of vanZTei and vanZg expression on resistance to glycopeptide antibiotics in Staphylococcus aureus |
| Ludmila Veselá | 2015 | diploma thesis | Influence of expression of lmr(C) on the biosynthesis of lincomycin in Streptomyces lincolnensis: Resistance or production? |
| Stanislav Kadlčík | 2014 | dissertation | Enzyme activities with potential for production of hybrid lincosamide antibiotics |
| Tomáš Kučera | 2014 | dissertation | Impact of the glycine-rich loop on the function of processing peptidases of the mitochondrial type |
| Magdaléna Pavlíková | 2013 | bachelor thesis | The use of parallel sequencing methods in microbiology |
| Lucie Steiningerová | 2013 | bachelor thesis | Common features of the biosynthetic pathways of lincomycin,some pyrrolo-1,4-benzodiazepines and hormaomycin |
| Šimon Vobruba | 2013 | bachelor thesis | Lessons from nature – preparation of hybrid bioactive compounds |
| Jakub Lenart | 2012 | diploma thesis | The effect of aminoacid variability on the resistance phenotype in ARE subfamily of ABC proteins |
| Petra Jiráčková | 2012 | diploma thesis | Preparation and characterization of LmbX protein involved in lincomycin biosynthesis |
| Dana Chytrá | 2012 | diploma thesis | Characterization of gycin-rich loop of mitochondrial processing peptidase alpha subunit from Saccharomyces cerevisiae |
| Ludmila Veselá | 2012 | bachelor thesis | Antibiotic resistance conferred by members of ARE subfamily of ABC proteins |
| Michaela Kroová | 2011 | diploma thesis | Molecular analysis of resistance gene vga(A)LC identification of key aminoacid residues |
| Markéta Koběrská | 2010 | dissertation | Comparative analysis of celesticetin and lincomycin biosynthetic gene clusters |
| Marek Poľan | 2010 | diploma thesis | Characterization of N-demethyllincomycin-methyltransferase |
| Petra Jiráčková | 2010 | bachelor thesis | The Shared Steps of Lincomycine and Pyrrolo-benzodiazepine Biosynthetic Pathways |
| Eliška Kettnerová | 2010 | bachelor thesis | Isolation and characterisation of biologically active substances |
| Dana Chytrá | 2010 | bachelor thesis | The Evolution of Mitochondrial Processing Peptidase and Its Substrates. |
| Tomáš Kučera | 2008 | diploma thesis | Characterization of signal peptidases of the mitochondrial type |
Institue of Microbiology
Institute of Microbiology, CAS
Vídeňská 1083, 142 20 Prague 4 - Krč
The Czech Republic
BIOCEV
Institute of Microbiology, CAS
Průmyslová 595, 252 50 Vestec
The Czech Republic
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